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      1. Author :
        Shi, Lei; Takahashi, Kazue; Dundee, Joseph; Shahroor-Karni, Sarit; Thiel, Steffen; Jensenius, Jens Christian; Gad, Faten; Hamblin, Michael R; Sastry, Kedarnath N; Ezekowitz, R Alan B
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2004
      5. Publication :
        The Journal of experimental medicine
      6. Products :
      7. Volume :
        199
      8. Issue :
        10
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Animals; Bioware; Disease Susceptibility; DNA, Bacterial; Lung; Mannose-Binding Lectin; Mice; Mice, Knockout; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Staphylococcal Infections; Xen8.1
      12. Abstract :
        Gram-positive organisms like Staphylococcus aureus are a major cause of morbidity and mortality worldwide. Humoral response molecules together with phagocytes play a role in host responses to S. aureus. The mannose-binding lectin (MBL, also known as mannose-binding protein) is an oligomeric serum molecule that recognizes carbohydrates decorating a broad range of infectious agents including S. aureus. Circumstantial evidence in vitro and in vivo suggests that MBL plays a key role in first line host defense. We tested this contention directly in vivo by generating mice that were devoid of all MBL activity. We found that 100% of MBL-null mice died 48 h after exposure to an intravenous inoculation of S. aureus compared with 45% mortality in wild-type mice. Furthermore, we demonstrated that neutrophils and MBL are required to limit intraperitoneal infection with S. aureus. Our study provides direct evidence that MBL plays a key role in restricting the complications associated with S. aureus infection in mice and raises the idea that the MBL gene may act as a disease susceptibility gene against staphylococci infections in humans.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/15148336
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :
        9994