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      1. Author :
      2. Title :
      3. Type :
        Journal Article
      4. Year :
      5. Publication :
        Journal of immunology (Baltimore, Md.: 1950)
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      10. Research Area :
      11. Keywords :
        Amine Oxidase (Copper-Containing); Animals; Bacterial Adhesion; Bioware; Cell Adhesion Molecules; Coxsackievirus Infections; Immunity, Mucosal; Immunoglobulin A; Lymphocyte Count; Lymphocytes; Lymphoid Tissue; Mice; Mice, Inbred C57BL; Mice, Knockout; Peyer's Patches; Receptors, Lymphocyte Homing; Staphylococcal Vaccines; Staphylococcus aureus; Xen36
      12. Abstract :
        VAP-1, an ecto-enzyme expressed on the surface of endothelial cells, is involved in leukocyte trafficking between the blood and tissues under physiological and pathological conditions. In this study, we used VAP-1-deficient mice to elucidate whether absence of VAP-1 alters the immune system under normal conditions and upon immunization and microbial challenge. We found that VAP-1-deficient mice display age-dependent paucity of lymphocytes, in the Peyer's patches of the gut. IgA concentration in serum was also found to be lower in VAP-1(-/-) animals than in wild-type mice. Although there were slightly less CD11a on B and T cells isolated from VAP-1-deficient mice than on those from wild-type mice, there were no differences in the expression of gut-homing-associated adhesion molecules or chemokine receptors. Because anti-VAP-1 therapies are being developed for clinical use to treat inflammation, we determined the effect of VAP-1 deletion on useful immune responses. Oral immunization with OVA showed defective T and B cell responses in VAP-1-deficient mice. Antimicrobial immune responses against Staphylococcus aureus and coxsackie B4 virus were also affected by the absence of VAP-1. Importantly, when the function of VAP-1 was acutely neutralized using small molecule enzyme inhibitors and anti-VAP-1 Abs rather than by gene deletion, no significant impairment in antimicrobial control was detected. In conclusion, VAP-1-deficient mice have mild deviations in the mucosal immune system and therapeutic targeting of VAP-1 does not appear to cause a generalized increase in the risk of infection.
      13. URL :
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :