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      1. Author :
        Kadurugamuwa, Jagath L; Sin, Lin V; Yu, Jun; Francis, Kevin P; Purchio, Tony F; Contag, Pamela R
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2004
      5. Publication :
        Antimicrobial agents and chemotherapy
      6. Products :
      7. Volume :
        48
      8. Issue :
        6
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Animals; Antibiotics, Antitubercular; Biofilms; Bioware; Colony Count, Microbial; Diagnostic Imaging; DNA-Directed RNA Polymerases; Luminescent Measurements; Mice; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Xen29
      12. Abstract :
        Eradication of Staphylococcus aureus biofilms after rifampin treatment was tested in a mouse model of device-related infection by using biophotonic imaging. Following treatment, the bioluminescent signals decreased to undetectable levels, irrespective of the age of the biofilm. After the final treatment, the signals rebounded in a time-dependent manner and reached those for the untreated mice. Readministration of rifampin was unsuccessful in eradicating reestablished infections, with the rifampin MICs for such bacteria being increased and with the bacteria having point mutations in the rpoB gene.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/15155235
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :
        9056