1. Resources
  2. Citations Library

Citation Details

You are viewing citation details. You can save or export citation(s) below, access an article, or start a new search.

1–1 of 1 record found matching your query:
Back to Search
Select All  |  Deselect All

Headers act as filters

      1. Author :
      2. Title :
      3. Type :
        Journal Article
      4. Year :
      5. Publication :
        Microbes and infection / Institut Pasteur
      6. Products :
      7. Volume :
      8. Issue :
      9. Page Numbers :
      10. Research Area :
      11. Keywords :
        Animals; Bacterial Proteins; Biofilms; Bioware; Catheterization, Central Venous; Male; Mice; Point Mutation; Sigma Factor; Staphylococcal Infections; Staphylococcus aureus; Virulence; Xen29
      12. Abstract :
        The impact of the alternative sigma factor sigma B (SigB) on pathogenesis of Staphylococcus aureus is not conclusively clarified. In this study, a central venous catheter (CVC) related model of multiorgan infection was used to investigate the role of SigB for the pathogenesis of S. aureus infections and biofilm formation in vivo. Analysis of two SigB-positive wild-type strains and their isogenic mutants revealed uniformly that the wild-type was significantly more virulent than the SigB-deficient mutant. The observed difference in virulence was apparently not linked to the capability of the strains to form biofilms in vivo since wild-type and mutant strains were able to produce biofilm layers inside of the catheter. The data strongly indicate that the alternative sigma factor SigB plays a role in CVC-associated infections caused by S. aureus.
      13. URL :
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :
Back to Search
Select All  |  Deselect All