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      1. Author :
        Gillrie, Mark R; Zbytnuik, Lori; McAvoy, Erin; Kapadia, Roxna; Lee, Kristine; Waterhouse, Christopher C M; Davis, Shevaun P; Muruve, Daniel A; Kubes, Paul; Ho, May
      2. Title :
      3. Type :
        Journal Article
      4. Year :
      5. Publication :
        European journal of immunology
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      11. Keywords :
        Animals; Bioware; Chemotaxis, Leukocyte; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Humans; Interferon-gamma; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Staphylococcal Infections; Staphylococcus aureus; Teichoic Acids; Toll-Like Receptor 2; Transplantation Chimera; Xen29
      12. Abstract :
        The response of leukocytes to lipoteichoic acid (LTA), a TLR2-dependent major cell wall component of Staphylococcus aureus, is linked to the outcome of an infection. In this study we investigated the role of nonhematopoietic TLR2 in response to LTA and S. aureus by creating bone marrow chimeras. Significant leukocyte recruitment in response to LTA required IFN-gamma priming in WT C57BL/6 and TLR2(-/-)-->WT mice, but was not observed in TLR2(-/-) or WT-->TLR2(-/-) animals. LTA also induced a proinflammatory response in IFN-gamma primed primary human microvascular endothelial cells leading to leukocyte recruitment in vitro. When mice were infected with S. aureus, the most profound elevation of TNF-alpha and IL-6 was seen in TLR2(-/-) and TLR2(-/-)-->WT mice. TLR2(-/-), but not chimeric mice, demonstrated increased IL-17, blood leukocytosis and pulmonary neutrophilia compared to WT mice. Collectively, the results suggest an essential role for IFN-gamma and nonhematopoietic TLR2 for leukocyte recruitment in response to LTA. In contrast, TLR2 on both hematopoietic and nonhematopoietic cells appears to orchestrate an inhibitory response to S. aureus such that in complete TLR2 deficiency, there is an exaggerated proinflammatory response and/or skewing of the immune response towards a Th17 phenotype that may contribute to the decreased survival of TLR2(-/-) mice.
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      14. Call Number :
        PKI @ catherine.lautenschlager @
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