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      1. Author :
        Park, Hae-Sun; Francis, Kevin P; Yu, Jun; Cleary, P Patrick
      2. Title :
      3. Type :
        Journal Article
      4. Year :
      5. Publication :
        Journal of immunology (Baltimore, Md.: 1950)
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      7. Volume :
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      9. Page Numbers :
      10. Research Area :
      11. Keywords :
        Administration, Intranasal; Animals; Bioware; Disease Models, Animal; Female; Humans; Immunohistochemistry; Intracellular Fluid; Lymphoid Tissue; Mice; Mice, Inbred BALB C; Nasal Mucosa; Nasopharynx; Palatine Tonsil; pXen-5; Streptococcal Infections; Streptococcus pyogenes
      12. Abstract :
        Human tonsils are suspected to be an antibiotic-impervious human reservoir for group A streptococcus. An intranasal infection model in mice and a bioluminescent-tagged strain were used to investigate this possibility. Viable streptococci were predominantly found both intra- and extracellularly in nasal-associated lymphoid tissue (NALT), a human tonsil homologue. Ulex europaeus-1, a membranous (M) cell-specific lectin, identified cells harboring streptococci at the epithelial surface of NALT and blocked bacterial colonization of this tissue. These results suggest that M cells in NALT transport this Gram-positive pathogen across the epithelial layers in a manner similar to those in Peyer's patches, which permit enteric pathogens to invade deeper tissues from the gastrointestinal tract.
      13. URL :
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :