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      1. Author :
        Neal, Robert E, 2nd; Singh, Ravi; Hatcher, Heather C; Kock, Nancy D; Torti, Suzy V; Davalos, Rafael V
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2010
      5. Publication :
        Breast cancer research and treatment
      6. Products :
      7. Volume :
        123
      8. Issue :
        1
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Animals; Bioware; Cell Line, Tumor; Electrochemotherapy; Electrodes; Female; Humans; Mammary Neoplasms, Experimental; MDA-MB-231-D3H1 cells; Mice; Mice, Nude; Needles; Xenograft Model Antitumor Assays
      12. Abstract :
        Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribution will slightly decrease if the same protocol were used on a tumor deep seated within a human breast. Tumor regression was observed in 5 out of 7 MDA-MB231 human mammary tumors orthotopically implanted in female Nu/Nu mice, with continued growth in controls.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/20191380
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :
        8988
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