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      1. Author :
        Kuo, Chaincy; Coquoz, Olivier; Troy, Tamara L; Xu, Heng; Rice, Brad W
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2007
      5. Publication :
        Journal of biomedical optics
      6. Products :
      7. Volume :
        12
      8. Issue :
        2
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Animals; Bioware; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Luminescent Proteins; Male; Mice; Microscopy, Fluorescence, Multiphoton; PC-3M-luc; Prostatic Neoplasms; Whole Body Imaging
      12. Abstract :
        A new method is described for obtaining a 3-D reconstruction of a bioluminescent light source distribution inside a living animal subject, from multispectral images of the surface light emission acquired on charge-coupled device (CCD) camera. The method uses the 3-D surface topography of the animal, which is obtained from a structured light illumination technique. The forward model of photon transport is based on the diffusion approximation in homogeneous tissue with a local planar boundary approximation for each mesh element, allowing rapid calculation of the forward Green's function kernel. Absorption and scattering properties of tissue are measured a priori as input to the algorithm. By using multispectral images, 3-D reconstructions of luminescent sources can be derived from images acquired from only a single view. As a demonstration, the reconstruction technique is applied to determine the location and brightness of a source embedded in a homogeneous phantom subject in the shape of a mouse. The technique is then evaluated with real mouse models in which calibrated sources are implanted at known locations within living tissue. Finally, reconstructions are demonstrated in a PC3M-luc (prostate tumor line) metastatic tumor model in nude mice.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/17477722
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :
        8968
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