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      1. Author :
        Abate, A.; Zhao, H.; Wong, R. J.; Stevenson, D. K.
      2. Title :
        The Role of Bach1 in the Induction of Heme Oxygenase by Tin Mesoporphyrin
      3. Type :
        Journal Article
      4. Year :
        2007
      5. Publication :
        Biochemical and Biophysical Research Communications
      6. Products :
      7. Volume :
        354
      8. Issue :
        N/A
      9. Page Numbers :
        757
      10. Research Area :
        N/A
      11. Keywords :
        IVIS, Xenogen
      12. Abstract :
        Tin mesoporphyrin (SnMP), a competitive heme oxygenase (HO) inhibitor, also induces HO-1 mRNA and protein expression by a mechanism that is not fully understood. We examined whether the induction by SnMP is mediated by a de-repression of Bach1, a transcription factor that suppresses the HO-1 gene. Incubation of NIH3T3-HO-1-luc cells with SnMP attenuated HO activity with a concomitant increase in HO-1 mRNA and protein and a decrease in Bach1 and HO-2 proteins, which was not due to transcriptional down-regulation, but accelerated protein decay. Similarly, HO-1 protein degradation was increased by SnMP, despite of an elevation in HO-1 transcription. Transfection of Bach1 shRNA in Hepa cells raised basal HO-1 expression significantly, and SnMP treatment further increased HO-1 mRNA. In conclusion, SnMP induces HO-1 expression not only by de-repressing the HO-1 promoter by binding Bach1, but also by accelerating Bach1 degradation.
      13. URL :
        N/A
      14. Call Number :
        135715
      15. Serial :
        7893
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