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      1. Author :
        Wu, C. C.; Lin, E. H.; Lee, Y. C.; Tai, C. J.; Kuo, T. H.; Wang, H. E.; Luo, T. Y.; Fu, Y. K.; Chen, H. J.; Sun, M. D.; Wu, C. H.; Wu, C. W.; Leu, S. J.; Deng, W. P.
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2010
      5. Publication :
        Journal of biomedicine & biotechnology
      6. Products :
      7. Volume :
        2010
      8. Issue :
        N/A
      9. Page Numbers :
        167045
      10. Research Area :
        N/A
      11. Keywords :
        N/A
      12. Abstract :
        A 12-mer amino acid peptide SATTHYRLQAAN, denominated TK4, was isolated from a phage-display library with fibrosarcoma tumor-binding activity. In vivo biodistribution analysis of TK4-displaying phage showed a significant increased phage titer in implanted tumor up to 10-fold in comparison with normal tissues after systemic administration in mouse. Competition assay confirmed that the binding of TK4-phage to tumor cells depends on the TK4 peptide. Intravenous injection of (131)I-labeled synthetic TK4 peptide in mice showed a tumor retention of 3.3% and 2.7% ID/g at 1- and 4-hour postinjection, respectively. Tumor-to-muscle ratio was 1.1, 5.7, and 3.2 at 1-, 4-, and 24-hour, respectively, and tumors were imaged on a digital gamma-camera at 4-hour postinjection. The present data suggest that TK4 holds promise as a lead structure for tumor targeting, and it could be further applied in the development of diagnostic or therapeutic agent.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/21151669
      14. Call Number :
        144472
      15. Serial :
        6368
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