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      1. Author :
        Lee, T. K.; Castilho, A.; Cheung, V. C.; Tang, K. H.; Ma, S.; Ng, I. O.
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2011
      5. Publication :
        Cell stem cell
      6. Products :
      7. Volume :
        9
      8. Issue :
        N/A
      9. Page Numbers :
        50
      10. Research Area :
        N/A
      11. Keywords :
        N/A
      12. Abstract :
        Tumor-initiating cells (T-ICs) are a subpopulation of chemoresistant tumor cells that have been shown to cause tumor recurrence upon chemotherapy. Identification of T-ICs and their related pathways are therefore priorities for the development of new therapeutic paradigms. We established chemoresistant hepatocellular carcinoma (HCC) xenograft tumors in immunocompromised mice in which an enriched T-IC population was capable of tumor initiation and self-renewal. With this model, we found CD24 to be upregulated in residual chemoresistant tumors when compared with bulk tumor upon cisplatin treatment. CD24(+) HCC cells were found to be critical for the maintenance, self-renewal, differentiation, and metastasis of tumors and to significantly impact patients' clinical outcome. With a lentiviral-based knockdown approach, CD24 was found to be a functional liver T-IC marker that drives T-IC genesis through STAT3-mediated NANOG regulation. Our findings point to a CD24 cascade in liver T-ICs that may provide an attractive therapeutic target for HCC patients.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/21726833
      14. Call Number :
        140170
      15. Serial :
        5652