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      1. Author :
        Marcella A. Calfon, Claudio Vinegoni, Vasilis Ntziachristos and Farouc A. Jaffer
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2010
      5. Publication :
        Journal of Biomedical Optics
      6. Products :
      7. Volume :
        15
      8. Issue :
        1
      9. Page Numbers :
        N/A
      10. Research Area :
        Cardiovascular Research
      11. Keywords :
        in vivo imaging; Cat K FAST; Cat B FAST; MMPSense
      12. Abstract :
        New imaging methods are urgently needed to identify high-risk atherosclerotic lesions prior to the onset of myocardial infarction, stroke, and ischemic limbs. Molecular imaging offers a new approach to visualize key biological features that characterize high-risk plaques associated with cardiovascular events. While substantial progress has been realized in clinical molecular imaging of plaques in larger arterial vessels (carotid, aorta, iliac), there remains a compelling, unmet need to develop molecular imaging strategies targeted to high-risk plaques in human coronary arteries. We present recent developments in intravascular near-IR fluorescence catheter-based strategies for in vivo detection of plaque inflammation in coronary-sized arteries. In particular, the biological, light transmission, imaging agent, and engineering principles that underlie a new intravascular near-IR fluorescence sensing method are discussed. Intravascular near-IR fluorescence catheters appear highly translatable to the cardiac catheterization laboratory, and thus may offer a new in vivo method to detect high-risk coronary plaques and to assess novel atherosclerosis biologics.
      13. URL :
        http://spiedl.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=JBOPFO000015000001011107000001&idtype=cvips&gifs=yes&ref=no
      14. Call Number :
        PKI @ sarah.piper @
      15. Serial :
        4556