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      1. Author :
        Bekeschus, S.; Mueller, A.; Miller, V.; Gaipl, U.; Weltmann, K.
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2018
      5. Publication :
        IEEE Transactions on Radiation and Plasma Medical Sciences
      6. Products :
      7. Volume :
        2
      8. Issue :
        2
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Cancer; fluorescence; cancer; antitumor immune responses; Argon; Atmospheric pressure argon plasma jet; biomembranes; calreticulin (CRT); Cathode ray tubes; cell membrane-bound calreticulin; cells underwent apoptosis; cellular biophysics; Colon; CRT translocation; CT26 colon cancer cells; CT26 murine colon cancer cells; damage-associated molecular pattern molecule; Fluorescence; Immune system; immunogenic cancer cell death; immunogenic cell death (ICD); kINPen; medical plasma; medicine expel reactive species; mitochondrial singlet oxygen; nanomedicine; patient treatment; plasma applications; plasma cancer cell death; plasma jet kINPen; plasma oncotherapy; plasma sources; plasma-treated cancer cells; Plasmas; tumours; viable as well as dead cells; Operetta CLS high-content analysis system; HCS; high-content
      12. Abstract :
        Plasma oncotherapy receives increasing attention due to considerable success in preclinical research. Different plasma sources were shown to induce cancer cell death in vitro and in vivo. Plasmas for medicine expel reactive species of many kinds. These have been implicated in the induction of immunogenic cancer cell death that increases the visibility of killed cells to the immune system. Cell membrane-bound calreticulin (CRT) serves as key damage-associated molecular pattern molecule to elicit antitumor immune responses. To investigate CRT translocation upon challenge with medical plasma, CT26 colon cancer cells were treated in vitro using the atmospheric pressure argon plasma jet kINPen. Cells underwent apoptosis, which was accompanied by exposure of CRT. Interestingly, CRT was upregulated on viable as well as dead cells, and remained upregulated up to 72 h post-treatment. Cell death was preceded by loss of membrane potential in mitochondria. These endosymbionts are capable of generating singlet oxygen, a molecule that has been suggested to drive radical chains in plasma cancer cell death. Using fluorescent probes, we identified a role of endogenous (mitochondrial-derived) over exogenous (plasma-derived) singlet oxygen in plasma-treated cancer cells.
      13. URL :
        N/A
      14. Call Number :
        PKI @ Kathryn.Cook @
      15. Serial :
        23031
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