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      1. Author :
        Montgomery, Samuel T.; Dittrich, A. Susanne; Garratt, Luke W.; Turkovic, Lidija; Frey, Dario L.; Stick, Stephen M.; Mall, Marcus A.; Kicic, Anthony; Arest Cf
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2018
      5. Publication :
        Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
      6. Products :
      7. Volume :
        N/A
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Airway epithelium; Cystic fibrosis; Hypoxia; Interleukin (IL)-1; Mucus; Neutrophilic inflammation
      12. Abstract :
        BACKGROUND: Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF.
        METHODS: Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans.
        RESULTS: IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). IL-1α had the strongest association with structural lung disease (p < 0.01) in the absence of infection (uninfected: p < 0.01 vs. infected: p = 0.122).
        CONCLUSION: Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target.
      13. URL :
        N/A
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :
        21068
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