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      1. Author :
        Abbasi, Azhar Z.; Prasad, Preethy; Cai, Ping; He, Chunsheng; Foltz, Warren D.; Amini, Mohammad Ali; Gordijo, Claudia R.; Rauth, Andrew M.; Wu, Xiao Yu
      2. Title :
      3. Type :
        Journal Article
      4. Year :
      5. Publication :
        Journal of Controlled Release
      6. Products :
      7. Volume :
      8. Issue :
      9. Page Numbers :
      10. Research Area :
      11. Keywords :
        Multifunctional nanoparticles; Manganese oxide; Cancer; Dual modal imaging; Drug delivery; IVIS; IVIS FLI
      12. Abstract :
        Multifunctional nanoparticles (NPs) have found important applications in diagnosis, chemotherapy, and image-guided surgery of tumors. In this work, we have developed polymeric theranostic NPs (PTNPs) containing the anticancer drug docetaxel (DTX), a fluorescent dye, and magnetic manganese oxide (MnO) NPs for dual modal imaging and chemotherapy. PTNPs ~ 150 nm in diameter were synthesized by co-loading hydrophobic DTX and MnO NPs ~ 5 nm in diameter, into the matrix of a fluorescent dye-labeled amphiphilic polymer. The PTNPs enabled high loading efficiency and sustained in vitro release of DTX. Energy-dependent cellular uptake and extended cytoplasmic retention of the PTNPs in MDA-MB-231 human breast cancer cells were observed by fluorescence microscopy examination. DTX-loaded PTNPs exhibited higher cytotoxicity than free DTX with a 3 to 4.4-fold decrease in drug dose required for 50% cell growth inhibition. The hydrophilic backbone of the amphiphilic polymer improved the fluidity of PTNPs which enhanced the longitudinal relaxivity (r1) of loaded MnO NPs by 2.7-fold with r1 = 2.4 mM− 1 s− 1. Whole body fluorescence imaging (FI) and magnetic resonance imaging (MRI) showed significant accumulation and prolonged retention of PTNPs in orthotopic MDA-MB-231 breast tumors. These results suggest that the new amphiphilic polymer-based PTNP system, able to simultaneously deliver a poorly soluble anticancer drug, enhance MRI contrast, and stain tumor tissue by fluorescence, is a good candidate for cancer theranostic applications.
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      14. Call Number :
        PKI @ user @ 9392
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