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      1. Author :
        Sharkey, Jack; Scarfe, Lauren; Santeramo, Ilaria; Garcia-Finana, Marta; Park, Brian K; Poptani, Harish; Wilm, Bettina; Taylor, Arthur; Murray, Patricia
      2. Title :
        Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease
      3. Type :
        Journal Article
      4. Year :
        2016
      5. Publication :
        European Journal of Pharmacology
      6. Products :
      7. Volume :
        N/A
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Stemcells; Preclinical imaging; Multispectral optoacoustictomography; Cell tracking; Biodistribution; Kidney Function Tests; IVIS; IVIS BLI in vivo
      12. Abstract :
        The incidenceofendstagekidneydiseaseisrisingannuallyanditisnowaglobalpublichealthproblem. Current treatmentoptionsaredialysisorrenaltransplantation,whichapartfromtheirsignificant drawbacksintermsofincreasedmorbidityandmortality,areplacinganincreasingeconomicburdenon society.Cell-basedRegenerativeMedicineTherapies(RMTs)haveshowngreatpromiseinrodentmodels of kidneydisease,butclinicaltranslationishamperedduetothelackofadequatesafetyandefficacy data. Furthermore,themechanismswherebythecell-basedRMTsameliorateinjuryareill-defined. For instance, itisnotalwaysclearifthecellsdirectlyreplacedamagedrenaltissue,orwhetherparacrine effects aremoreimportant.Knowledgeofthemechanismsresponsibleforthebeneficial effectsofcell therapies iscrucialbecauseitcouldleadtothedevelopmentofsaferandmoreeffectiveRMTsinthe future. Toaddressthesequestions,novelinvivoimagingstrategiesareneededtomonitorthebiodis- tribution ofcell-basedRMTsandevaluatetheirbeneficial effectsonhosttissuesandorgans,aswellas anypotentialadverseeffects.Inthisreviewwewilldiscusshowstate-of-the-artimagingmodalities, including bioluminescence,magneticresonance,nuclearimaging,ultrasoundandanemergingimaging technology calledmultispectraloptoacoustictomography,canbeusedincombinationwithvarious imaging probestotrackthefateandbiodistributionofcell-basedRMTsinrodentmodelsofkidney disease, andevaluatetheireffectonrenalfunction.
      13. URL :
        N/A
      14. Call Number :
        PKI @ user @ 11867
      15. Serial :
        19504