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      1. Author :
        Korupalli, Chiranjeevi; Huang, Chieh-Cheng; Lin, Wei-Chih; Pan, Wen-Yu; Lin, Po-Yen; Wan, Wei-Lin; Li, Meng-Ju; Chang, Yen; Sung, Hsing-Wen
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Biomaterials
      6. Products :
      7. Volume :
        116
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Subcutaneous abscesses; Photothermal therapy; pH-responsive nanoparticles; Charge conversion; Imaging guiding; IVIS; IVIS FLI in vivo
      12. Abstract :
        Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood. The local temperature of the NIR-irradiated PANI-GCS NPs is estimated to be approximately 5 °C higher than their ambient tissue temperature, ensuring specific and direct heating of their aggregated bacteria; hence, damage to tissue is reduced and wound healing is accelerated. The above results demonstrate that PANI-GCS NPs are practical for use in the photothermal ablation of focal infections.
      13. URL :
        http://www.sciencedirect.com/science/article/pii/S014296121630669X
      14. Call Number :
        PKI @ catherine.lautenschlager @ 12976
      15. Serial :
        13983