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      1. Author :
        Pan, Pengyu; Zhang, Xuan; Li, Qiang; Zhao, Hengli; Qu, Jie; Zhang, John H.; Liu, Xin; Feng, Hua; Chen, Yujie
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Neuroscience Letters
      6. Products :
      7. Volume :
        649
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Subarachnoid hemorrhage; Early brain injury; Cyclosporine A; Blood-brain barrier; Matrix metalloproteinase 9; IVIS; IVIS FLI in vivo
      12. Abstract :
        The aim of this study was to investigate whether Cyclosporine A (CsA) attenuates early brain injury by alleviating matrix metalloproteinase 9 (MMP-9) associated blood-brain barrier (BBB) disruption after subarachnoid hemorrhage (SAH). A standard intravascular perforation model was used to produce the experimental SAH in C57B6J mice. Dosages of 5mg/kg, 10mg/kg and 15mg/kg CsA were evaluated for effects on neurological score, brain water content, Evans blue extravasation and fluorescence, P-p65, MMP-9 and BBB components’ alterations after SAH. We found that CsA 15mg/kg is effective in attenuating BBB disruption, lowering edema, and improving neurological outcomes. In addition, Collagen IV, ZO-1, Occludin and Claudin 5 expressions in ipsilateral/left hemisphere were downregulated after SAH, but increased after CsA treatment. Our results suggest that CsA exert a neuroprotective role in SAH pathophysiology, possibly by alleviating MMP-9 associated BBB disruption.
      13. URL :
        http://www.sciencedirect.com/science/article/pii/S030439401730280X
      14. Call Number :
        PKI @ catherine.lautenschlager @ 13591
      15. Serial :
        13825