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      1. Author :
        Zheng, Bin; Wang, Jingya; Pan, Huizhuo; Chen, Hongbin; Ji, Wanying; Liao, Zhenyu; Gong, Xiaoqun; Wang, Hanjie; Chang, Jin
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Journal of Colloid and Interface Science
      6. Products :
      7. Volume :
        506
      8. Issue :
        Supplement C
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Synergy therapy; Gene therapy; Photothermal therapy; Tungsten oxide nanocrystals; IVIS; IVIS FLI in vivo
      12. Abstract :
        Combination of gene therapy and photothermal therapy (PTT) has drawn much attention in cancer therapy in recent years. However, this joint treatment process lacks fluorescence imaging visualization guidance that limits its clinical applications in oncotherapy. Herein, we report the use of gene therapy and tungsten oxide (W18O49, WO) synthetized with template method for combined PTT of cancer. In this system, a novel nanoplatform, with Bax gene, WO and indocyanine green (ICG) loaded in mesoporous silica nanoparticle had been successfully constructed, which was used as the near-infrared imaging-guided gene/optothermal multi-modal oncotherapy. These nanoparticles could achieve a synergistic therapy effect of gene therapy and PTT for tumor under 808nm near-infrared (NIR) laser excitation. In vivo animal experiments showed that they could cause solid tumor regression under 808nm NIR light irradiation, revealing the potential of these nanocomposites as a fluorescence imaging-guided multi-modal therapeutic nanosystem for tumor visual synergistic treatment.
      13. URL :
        http://www.sciencedirect.com/science/article/pii/S0021979717308445
      14. Call Number :
        PKI @ catherine.lautenschlager @ 14113
      15. Serial :
        13553