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      1. Author :
        Yamaoka, Ippei; Kikuchi, Takeshi; Endo, Naoyuki; Ebisu, Goro
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2014
      5. Publication :
        BMC gastroenterology
      6. Products :
      7. Volume :
        14
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        BALB/c CrSlc mice; enteral nutrition; Ex vivo; Gastrosense 750; Hine® E-gel; in vivo; IVIS® Spectrum; Nev11121; pectin
      12. Abstract :
        BACKGROUND: Semi-solidification by gelation or increased viscosity could slow the influx of liquid enteral nutrition (EN) into the small intestine. A liquid EN formula containing pectin that gels under acidic conditions such as those found in the stomach has been developed. A new near-infrared fluorescent imaging reagent was used to non-invasively acquire real time images of gastric emptying in a murine model in vivo. We postulated that the EN formula delays gastric emptying and tested this hypothesis using imaging in vivo.
        METHODS: Male BALB/c mice were given an oral bolus injection of a liquid EN containing the fluorescence reagent GastroSense750 with or without pectin. The EN in the stomach was visualized in vivo at various intervals using a non-invasive live imaging system and fluorescent signals were monitored from the stomach, which was removed at 60 min after EN ingestion.
        RESULTS: The fluorescence intensity of signals in stomachs in vivo and in resected stomachs was lower and attenuated over time in mice given EN without, than with pectin.
        CONCLUSIONS: Adding a gelling agent such as pectin delayed the transit of liquid EN from the stomach. Fluorescence imaging can visualize the delayed gastric emptying of EN containing pectin.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/25263497
      14. Call Number :
        PKI @ catherine.lautenschlager @
      15. Serial :
        11641