1. Resources
  2. Citations Library

Citation Details

You are viewing citation details. You can save or export citation(s) below, access an article, or start a new search.

1–1 of 1 record found matching your query:
Back to Search
Select All  |  Deselect All

Headers act as filters

      1. Author :
        Kim, J. K.; Won, Y. W.; Lim, K. S.; Kim, Y. H.
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2012
      5. Publication :
        Pharm Res
      6. Products :
      7. Volume :
        29
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        IVIS, B16-F10-luc-G5, B16F10-luc-G5, B16-F10-luc, B16F10-luc, Animals; Antineoplastic Agents/*administration & dosage/pharmacokinetics/therapeutic use; Delayed-Action Preparations/*chemistry; Male; Methylcellulose/*chemistry; Mice; Mice, Inbred C57BL; *Micelles; Neoplasms/drug therapy; Poloxamer/*chemistry; Taxoids/*administration & dosage/pharmacokinetics/therapeutic use
      12. Abstract :
        PURPOSE: To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX). METHODS: LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model. RESULTS: Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40 degrees C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX. CONCLUSIONS: The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/21904934
      14. Call Number :
        PKI @ kd.modi @ 16
      15. Serial :
        10531
Back to Search
Select All  |  Deselect All