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      1. Author :
        Huang, Binghuan; Geng, Zhirong; Yan, Shihai; Li, Zan; Cai, Jun; Wang, Zhilin
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Analytical Chemistry
      6. Products :
      7. Volume :
        89
      8. Issue :
        17
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Maestro
      12. Abstract :
        Adenosine triphosphate (ATP) is used as the energy source in cells and plays crucial roles in various cellular events. The cellular membrane is the protective barrier for the cytoplasm of living cells and involved in many essential biological processes. Many fluorescent probes for ATP have been successfully developed, but few of these probes were appropriate for visualizing ATP level fluctuation in cell membranes during the apoptotic cell death process. Herein, we report the synthesis of a new water-soluble cationic polythiophene derivative that can be utilized as a fluorescent sensor for detecting ATP in cell membranes. Poly((3-((4-methylthiophen-3-yl)oxy)propyl)triphenylphosphonium chloride) (PMTPP) exhibits high sensitivity and good selectivity to ATP, and the detection limit is 27 nM. The polymer shows low toxicity to live cells and excellent photostability in cell membranes. PMTPP was practically utilized for real-time monitoring of ATP levels in the cell membrane through fluorescence microscopy. We have demonstrated that the ATP levels in cell membranes increased during the apoptotic cell death process. The probe was also capable of imaging ATP levels in living mice.
      13. URL :
        http://dx.doi.org/10.1021/acs.analchem.7b01212 http://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b01212
      14. Call Number :
        PKI @ catherine.lautenschlager @ 14146
      15. Serial :
        12852
      1. Author :
        Hwang, Do Won; Bahng, Namryeong; Ito, Kenichiro; Ha, Seunggyun; Kim, Mee Young; Lee, Eunji; Suga, Hiroaki; Lee, Dong Soo
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Cancer Letters
      6. Products :
      7. Volume :
        385
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        c-Met (hepatocyte growth factor receptor); Random non-standard Peptides Integrated Discovery (RaPID); Fluorescence-labeled macrocyclic c-Met peptide; Cancer targeting study; Tumor receptor imaging; Maestro
      12. Abstract :
        Development of c-Met targeting probes based on specifically designed peptides with high affinity and stability could help enhance diagnostic efficacy and therapeutic effects in c-Met positive cancers. The Random non-standard Peptides Integrated Discovery (RaPID) system for synthesizing natural product-like macrocyclic peptides via in vitro translation-based selection has recently emerged to overcome the shortcomings of traditional peptide synthesis. Here, we developed non-standard macrocyclic peptides specific to c-Met, and examined the cancer-targeting efficiency of fluorescein-labeled (FL) anti-c-Met peptides, referred to as aML5-FL and aMD4-FL, both in vitro and in vivo. The aML5-FL effectively targeted SNU-638 gastric cancer cells with high c-Met expression, compared to the aMD4-FL due to its high affinity. After intravenous administration of aML5-FL in a tumor xenograft mouse model, FL signal intensity in the extracted SNU-638 tumors was higher than that in SNU-216 tumors. This study provides preclinical data for the usefulness of novel non-standard macrocyclic peptides developed by the RaPID system for specific biomarker imaging.
      13. URL :
        http://www.sciencedirect.com/science/article/pii/S0304383516306619
      14. Call Number :
        PKI @ catherine.lautenschlager @ 12644
      15. Serial :
        12850
      1. Author :
        Liu, Lanlan; Yi, Huqiang; He, Huamei; Pan, Hong; Cai, Lintao; Ma, Yifan
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Biomaterials
      6. Products :
      7. Volume :
        134
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Tumor-associated macrophages; Nanoparticles; Targeted delivery; miR155; Cancer therapy; Maestro
      12. Abstract :
        Repolarizing Tumor-associated macrophages (TAMs) to anti-tumor M1 macrophages with microRNA (miR) is a plausible approach for cancer treatment. However, how to achieve TAM-targeted miR delivery remains a challenge. The present study generated redox/pH dual-responsive hybrid polypeptide nanovectors, which consisted of self-crosslinked redox-responsive nanoparticles based on galactose-functionalized n-butylamine-poly(l-lysine)-b-poly(l-cysteine) polypeptides (GLC) coated with DCA-grafted sheddable PEG-PLL (sPEG) copolymers. The ex vivo study showed that sPEG shielded cationic GLC core at physiological pH but quickly shed off to re-expose GLC due to it charge reversible property. Encapsulation with sPEG/GLC nanovectors effectively facilitated macrophage-targeted miR delivery at the acidic condition but diminished miR uptake at neutral pH. Administration of miR155-loaded sPEG/GLC (sPEG/GLC/155) nanocomplexes increased miR155 expression in TAMs about 100–400 folds both in vitro and in vivo. sPEG/GLC/155 also effectively repolarized immunosuppressive TAMs to anti-tumor M1 macrophages through elevating M1 macrophage markers (IL-12, iNOS, MHC II) and suppressing M2 macrophage markers (Msr2 and Arg1) in TAMs. Moreover, the treatment of sPEG/GLC/155 significantly increased activated T lymphocytes and NK cells in tumors, which consequently led to robust tumor regression. Hence, TAM-targeted delivery of miR with redox/pH dual-responsive sPEG/GLC nanovectors could be a promising approach to re-polarize TAMs to M1 macrophages in situ and induce tumor regression.
      13. URL :
        http://www.sciencedirect.com/science/article/pii/S0142961217302806
      14. Call Number :
        PKI @ catherine.lautenschlager @ 13760
      15. Serial :
        12840
      1. Author :
        Liang, Jie; Dong, Xia; Wei, Chang; Ma, Guilei; Liu, Tianjun; Kong, Deling; Lv, Feng
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Carbohydrate Polymers
      6. Products :
      7. Volume :
        175
      8. Issue :
        Supplement C
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        α-Cyclodextrin; Porphyrin-poly(ethylene glycol); Carbon nanotubes; Fluorescence imaging tracking; Photothermal response; Maestro
      12. Abstract :
        The real-time controlling and tracking of the evolution and status of the hydrogel are important challenges for accurate and precise assessments. In this article, a visible and controllable hydrogel nanocomposites system for photo response was designed and developed based on a thermosensitive porphyrin-poly(ethylene glycol)/α-cyclodextrin hydrogel loaded with multi-walled carbon nanotubes (PPEG-MWNTs/α-CD). The PPEG-MWNTs/α-CD hydrogel was simply self-assembled with a carbon nanotubes dispersed porphyrin-poly(ethylene glycol) solution and an aqueous solution of α-cyclodextrin by homogeneous stirring. The structure and the optical and photothermal abilities of the hydrogel nanocomposites system were characterized in vitro. Moreover, the controlled disassembly of the hydrogel was monitored in real time by in vivo fluorescence imaging after subcutaneous injection using mice as models. The results demonstrated that the hydrogel disassembly can be efficiently accelerated under laser irradiation with the loading of carbon nanotubes by fluorescence imaging visualization. With the advantages of the photo response, fluorescence imaging tracking and photothermal remote controlling were combined into the hydrogel nanocomposites system.
      13. URL :
        http://www.sciencedirect.com/science/article/pii/S0144861717308901
      14. Call Number :
        PKI @ catherine.lautenschlager @ 14188
      15. Serial :
        12841
      1. Author :
        Liang, Jie; Dong, Xia; Wei, Chang; Kong, Deling; Liu, Tianjun; Lv, Feng
      2. Title :
        Phthalocyanine incorporated alginate hydrogel with near infrared fluorescence for non-invasive imaging monitoring in vivo
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        RSC Advances
      6. Products :
      7. Volume :
        7
      8. Issue :
        11
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Maestro
      12. Abstract :
        In vivo fates of alginate compounds are crucial for developing their biomedical applications. Near infrared fluorescence imaging in vivo can non-invasively monitor and reveal the process of the implants. Herein, a near infrared fluorescent alginate conjugated PEG was prepared by labeling zinc phthalocyanine, and then a dual fluorescent drug delivery system was designed with a rhodamine-loaded zinc phthalocyanine conjugated hydrogel. The hydrogel erosion and drug delivery in vivo were non-invasively tracked by a multispectral fluorescence imaging system with nude mice as models. The in vivo near infrared fluorescence imaging results revealed the real time process of the visible drug delivery system based on the alginate hydrogel. A multispectral fluorescence imaging technique can separate the fluorescence signals of the drug and the carrier from the drug-loaded hydrogel. The phthalocyanine-incorporated alginate hydrogel is a potential visible implant system.
      13. URL :
        N/A
      14. Call Number :
        PKI @ catherine.lautenschlager @ 13216
      15. Serial :
        12842
      1. Author :
        Li, Xiaodan; Gao, Min; Xin, Keting; Zhang, Ling; Ding, Dan; Kong, Deling; Wang, Zheng; Shi, Yang; Kiessling, Fabian; Lammers, Twan; Cheng, Jianjun; Zhao, Yanjun
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Journal of Controlled Release
      6. Products :
      7. Volume :
        260
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Micelles; Photodynamic therapy; Singlet oxygen-responsive; Imidazole; Drug delivery; Maestro
      12. Abstract :
        Photodynamic therapy (PDT) efficacy is limited by the very short half-life and limited diffusion radius of singlet oxygen (1O2). We report a 1O2-responsive micellar nanoplatform subject to considerable size-expansion upon light triggering to facilitate on-demand release of photosensitizers. Imidazole, a well-known 1O2 scavenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and was used to coordinate with biocompatible Zn2+ and encapsulate the photosensitizer chlorin e6 (Ce6). The micelles are highly sensitive to light irradiation: 1O2 triggering induced dramatic particle size expansion due to the conversion of imidazole to hydrophilic urea, resulting in instantaneous release of Ce6 and rapid intracellular distribution. This 1O2-responsive, size-expandable nanosystem delivered substantially more Ce6 to tumor sites as compared to free Ce6, and exhibited improved anti-tumor efficacy in vivo in 4T1 tumor-bearing mice. This work opens new avenues of particle expansion-induced PDT enhancement by controlled imidazole chemistry.
      13. URL :
        http://www.sciencedirect.com/science/article/pii/S0168365917305989
      14. Call Number :
        PKI @ catherine.lautenschlager @ 13900
      15. Serial :
        12843
      1. Author :
        Li, Fang; Xing, Qingguo; Han, Yingchao; Li, Yue; Wang, Wei; Perera, Thalagalage Shalika Harshani; Dai, Honglian
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Materials Science and Engineering: C
      6. Products :
      7. Volume :
        80
      8. Issue :
        Supplement C
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Ultrasonic synthesis; Poly(acrylic acid); Calcium phosphate; Hybrid nanogels; pH-sensitive drug carriers; Controlled delivery; Maestro
      12. Abstract :
        Biocompatible, biodegradable and stimuli-responsive nanomaterials can be used as drug carriers and to achieve controlled drug delivery, which is crucial for treating tumors and lowering drug side effects. Calcium phosphate (CaP) nanoparticles and poly(acrylic acid) (PAA) hydrogels can be used as biocompatible and pH-responsive drug carriers. In this study, based on the ultrasound effect, PAA/CaP hybrid nanogels (approximately 100nm, PDI<0.2) are obtained via the cross-linking of CaP nanoparticles and PAA molecules between the Ca2+ ions and –COOH groups. The PAA/CaP hybrid nanogels show good stability in biological media as well as no hemolysis and no cytotoxicity to L02 cells. Moreover, the PAA/CaP hybrid nanogels display an enhanced loading capacity (approximately 32%) for doxorubicin hydrochloride (DOX) compared to pure CaP nanoparticles (approximately 7.5%) and a pH-controlled drug release due to their dissolution in acidic environment. DOX can be delivered into cancer cells by the PAA/CaP hybrid nanogels, which show an inhibitory effect comparable to that of free DOX, although the inhibitory effect is delayed due to the slow release of DOX from the carriers. In vivo, the PAA/CaP hybrid nanogels cannot avoid the capture by the reticuloendothelial system; however, they show passive tumor targeting ability. In brief, the biocompatible, biodegradable and pH-responsive PAA/CaP hybrid nanogels have the potential to act as drug carriers for controlled drug release.
      13. URL :
        http://www.sciencedirect.com/science/article/pii/S0928493117315151
      14. Call Number :
        PKI @ catherine.lautenschlager @ 14105
      15. Serial :
        12844
      1. Author :
        Leng, Jingning; Chen, Jingyi; Wang, Dan; Wang, Jie-Xin; Pu, Yuan; Chen, Jian-Feng
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Industrial & Engineering Chemistry Research
      6. Products :
      7. Volume :
        56
      8. Issue :
        28
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Maestro
      12. Abstract :
        Optically transparent upconversion luminescent organic–inorganic nanocomposites are of great significance in many fields. The related key science problems are how to control size and uniformity of upconversion nanophosphors, as well as the dispersity of the upconversion nanophosphors in transparent polymer matrix. In this article, we reported a novel route to prepare Gd2O3:Yb3+/Er3+ nanophosphors by high gravity reactive precipitation along with post hydrothermal and calcination process. A rotating packed bed (RPB) reactor was used to create a high-gravity environment for intensified mixing during the precipitation process of particles. The as-prepared Gd2O3:Yb3+/Er3+ nanoparticles exhibited uniform particle size of <100 nm, which is much smaller than the common route (∼350 nm). After surface modification, they were also homogeneously mixed with commercial polyurethane (PU), forming flexible transparent composites. The transparent film of Gd2O3:Yb3+/Er3+-PU showed bright visible luminescence under near-infrared light irradiation, promising for upgrades of photovoltaic, photocatalysis, and wearable optoelectronics.
      13. URL :
        http://dx.doi.org/10.1021/acs.iecr.7b02262 http://pubs.acs.org/doi/abs/10.1021/acs.iecr.7b02262
      14. Call Number :
        PKI @ catherine.lautenschlager @ 14040
      15. Serial :
        12845
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