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      1. Author :
        Scott A Hilderbranda; Ralph Weissleder
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2010
      5. Publication :
        Current Opinion in Chemical Biology
      6. Products :
      7. Volume :
        14
      8. Issue :
        1
      9. Page Numbers :
        N/A
      10. Research Area :
        Biology; Cell Biology
      11. Keywords :
        in vivo imaging; molecular imaging; fluorescence imaging; fluorescence molecular tomography; FMT; Fluorescence Imaging Agents
      12. Abstract :
        Molecular imaging often relies on the use of targeted and activatable reporters to quantitate and visualize targets, biological processes, and cells in vivo. The use of optical probes with near-infrared fluorescence allows for improved photon penetration through tissue and minimizes the effects of tissue autofluorescence. There are several parameters that define the effectiveness of imaging agents in vivo. These factors include probe targeting, activation, pharmacokinetics, biocompatibility, and photophysics. Recent advances in our understanding of these variables as they pertain to the application of optical reporters for in vivo imaging are discussed in this review.
      13. URL :
        http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VRX-4XK2SWH-1&_user=10&_coverDate=02%2F28%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=01a365937cece132c
      14. Call Number :
        PKI @ sarah.piper @
      15. Serial :
        4471
      1. Author :
        Zhang, Cen; Liu, Juan; Zhao, Yuhan; Yue, Xuetian; Zhu, Yu; Wang, Xiaolong; Wu, Hao; Blanco, Felix; Li, Shaohua; Bhanot, Gyan; Haffty, Bruce G; Hu, Wenwei; Feng, Zhaohui
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2016
      5. Publication :
        eLife
      6. Products :
      7. Volume :
        N/A
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        IVIS; IVIS BLI in vivo
      12. Abstract :
        Glutaminase (GLS) isoenzymes GLS1 and GLS2 are key enzymes for glutamine metabolism. Interestingly, GLS1 and GLS2 display contrasting functions in tumorigenesis with elusive mechanism; GLS1 promotes tumorigenesis, whereas GLS2 exhibits a tumor suppressive function. In this study, we found that GLS2 but not GLS1 binds to small GTPase Rac1 and inhibits its interaction with Rac1 activators guanine-nucleotide exchange factors (GEFs), which in turn inhibits Rac1 to suppress cancer metastasis. This function of GLS2 is independent of GLS2 glutaminase activity. Furthermore, decreased GLS2 expression is associated with enhanced metastasis in human cancer. As a p53 target, GLS2 mediates p53's function in metastasis suppression through inhibiting Rac1. In summary, our results reveal that GLS2 is a novel negative regulator of Rac1, and uncover a novel function and mechanism whereby GLS2 suppresses metastasis. Our results also elucidate a novel mechanism that contributes to the contrasting functions of GLS1 and GLS2 in tumorigenesis.
      13. URL :
        http://elifesciences.org/elife/early/2016/01/11/eLife.10727.full.pdf
      14. Call Number :
        PKI @ user @ 10753
      15. Serial :
        19311
      1. Author :
        Kong, Miao; Tang, Jiamin; Qiao, Qi; Wu, Tingting; Qi, Yan; Tan, Songwei; Gao, Xueqin; Zhang, Zhiping
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        Theranostics
      6. Products :
      7. Volume :
        7
      8. Issue :
        13
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        nanoparticles; tumor microenvironment; immunosuppression; drug delivery; cancer treatment; IVIS; IVIS FLI in vivo
      12. Abstract :
        There is accumulating evidence that regulating tumor microenvironment plays a vital role in improving antitumor efficiency. Herein, to remodel tumor immune microenvironment and elicit synergistic antitumor effects, lipid-coated biodegradable hollow mesoporous silica nanoparticle (dHMLB) was constructed with co-encapsulation of all-trans retinoic acid (ATRA), doxorubicin (DOX) and interleukin-2 (IL-2) for chemo-immunotherapy. The nanoparticle-mediated combinational therapy provided a benign regulation on tumor microenvironment through activation of tumor infiltrating T lymphocytes and natural killer cells, promotion of cytokines secretion of IFN-γ and IL-12, and down-regulation of immunosuppressive myeloid-derived suppressor cells, cytokine IL-10 and TGF-β. ATRA/DOX/IL-2 co-loaded dHMLB demonstrated significant tumor growth and metastasis inhibition, and also exhibited favorable biodegradability and safety. This nanoplatform has great potential in developing a feasible strategy to remodel tumor immune microenvironment and achieve enhanced antitumor effect.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595131/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595131/pdf/thnov07p3276.pdf
      14. Call Number :
        PKI @ catherine.lautenschlager @ 14163
      15. Serial :
        13985
      1. Author :
        Kim, Yi Rang; Kim, Seonghoon; Choi, Jin Woo; Choi, Sung Yong; Lee, Sang-Hee; Kim, Homin; Hahn, Sei Kwang; Koh, Gou Young; Yun, Seok Hyun
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2015
      5. Publication :
        Theranostics
      6. Products :
      7. Volume :
        5
      8. Issue :
        8
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Photodynamic Therapy,; Bioluminescence,; Photosensitizers,; Resonance Energy Transfer,; Cancer, Photobiology, Photomedicine; IVIS; IVIS BLI in vivo
      12. Abstract :
        Optical energy can trigger a variety of photochemical processes useful for therapies. Owing to the shallow penetration of light in tissues, however, the clinical applications of light-activated therapies have been limited. Bioluminescence resonant energy transfer (BRET) may provide a new way of inducing photochemical activation. Here, we show that efficient bioluminescence energy-induced photodynamic therapy (PDT) of macroscopic tumors and metastases in deep tissue. For monolayer cell culture in vitro incubated with Chlorin e6, BRET energy of about 1 nJ per cell generated as strong cytotoxicity as red laser light irradiation at 2.2 mW/cm(2) for 180 s. Regional delivery of bioluminescence agents via draining lymphatic vessels killed tumor cells spread to the sentinel and secondary lymph nodes, reduced distant metastases in the lung and improved animal survival. Our results show the promising potential of novel bioluminescence-activated PDT.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440439/
      14. Call Number :
        PKI @ user @ 9294
      15. Serial :
        20694
      1. Author :
        Barman, T. K.; Rao, M.; Bhati, A.; Kishore, K.; Shukla, G.; Kumar, M.; Mathur, T.; Pandya, M.; Upadhyay, D. J.
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2011
      5. Publication :
        Indian J Med Res
      6. Products :
      7. Volume :
        134
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Xen10, Xen 10, Streptococcus pnuemoniae Xen10, IVIS,
      12. Abstract :
        Background & objectives: In vivo imaging system has contributed significantly to the understanding of bacterial infection and efficacy of drugs in animal model. We report five rapid, reproducible, and non invasive murine pulmonary infection, skin and soft tissue infection, sepsis, and meningitis models using Xenogen bioluminescent strains and specialized in vivo imaging system (IVIS). Methods: The progression of bacterial infection in different target organs was evaluated by the photon intensity and target organ bacterial counts. Genetically engineered bioluminescent bacterial strains viz. Staphylococcus aureus Xen 8.1, 29 and 31; Streptococcus pneumoniae Xen 9 and 10 and Pseudomonas aeruginosa Xen-5 were used to induce different target organs infection and were validated with commercially available antibiotics. Results: The lower limit of detection of colony forming unit (cfu) was 1.7-log10 whereas the lower limit of detection of relative light unit (RLU) was 4.2-log10 . Recovery of live bacteria from different target organs showed that the bioluminescent signal correlated to the live bacterial count. Interpretation & conclusions: This study demonstrated the real time monitoring and non-invasive analysis of progression of infection and pharmacological efficacy of drugs. These models may be useful for pre-clinical discovery of new antibiotics.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/22199109
      14. Call Number :
        PKI @ kd.modi @ 3
      15. Serial :
        10399
      1. Author :
        Ibarra, J. M.; Jimenez, F.; Martinez, H. G.; Clark, K.; Ahuja, S. S.
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2011
      5. Publication :
        Int J Inflam
      6. Products :
      7. Volume :
        2011
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        MMPSense, IVIS
      12. Abstract :
        The Standard measures of experimental arthritis fail to detect, visualize, and quantify early inflammation and disease activity. Here, we describe the use of an injectable MMP-activated fluorescence agent for in vivo quantification of acute inflammation produced by collagen-antibody-induced arthritis (CAIA) in CC chemokine receptor-2 (Ccr2(-/-)) null mice. Although Ccr2(-/-) DBA1/J mice were highly susceptible to and rapidly developed CAIA, the standard clinical assessment of fore or hind paw thicknesses was unable to detect significant acute inflammatory changes (days 3-10). Remarkably, noninvasive, in situ, MMP-activatable fluorescent imaging of Ccr2(-/-) DBA1/J mice with CAIA displayed acute joint pathology in advance of clinically measurable acute inflammation (days 5, 7, and 10). These results were confirmed by the histology of ankle joints, which showed significant inflammation, bone loss, and synovial hyperplasia, compared to control mice at postimmunization day 5. The MMP-mediated fluorescence technique holds tremendous implications for quantifiable examination of arthritis disease activity of acute joint inflammation.
      13. URL :
        http://www.ncbi.nlm.nih.gov/pubmed/21755029
      14. Call Number :
        PKI @ kd.modi @ 4
      15. Serial :
        10462
      1. Author :
        Freund-Brown, Jacquelyn; Choa, Ruth; Singh, Brenal K.; Robertson, Tanner Ford; Ferry, Gabrielle M.; Viver, Eric; Bassiri, Hamid; Burkhardt, Janis K.; Kambayashi, Taku
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        The Journal of Immunology
      6. Products :
      7. Volume :
        N/A
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        Ivis; Ivis Bli
      12. Abstract :
        Sustained Ca2+ signaling, known as store-operated calcium entry (SOCE), occurs downstream of immunoreceptor engagement and is critical for cytotoxic lymphocyte signaling and effector function. CD8+ T cells require sustained Ca2+ signaling for inflammatory cytokine production and the killing of target cells; however, much less is known about its role in NK cells. In this study, we use mice deficient in stromal interacting molecules 1 and 2, which are required for SOCE, to examine the contribution of sustained Ca2+ signaling to murine NK cell function. Surprisingly, we found that, although SOCE is required for NK cell IFN-γ production in an NFAT-dependent manner, NK cell degranulation/cytotoxicity and tumor rejection in vivo remained intact in the absence of sustained Ca2+ signaling. Our data suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes.%U http://www.jimmunol.org/content/jimmunol/early/2017/08/09/jimmunol.1700340.full.pdf
      13. URL :
        N/A
      14. Call Number :
        PKI @ catherine.lautenschlager @ 14200
      15. Serial :
        14093
      1. Author :
        Ranganathan, Parvathi; Ngankeu, Apollinaire; Zitzer, Nina C.; Leoncini, PierPaolo; Yu, Xueyan; Casadei, Lucia; Challagundla, Kishore; Reichenbach, Dawn K.; Garman, Sabrina; Ruppert, Amy S.; Volinia, Stefano; Hofstetter, Jessica; Efebera, Yvonne A.; Devine, Steven M.; Blazar, Bruce R.; Fabbri, Muller; Garzon, Ramiro
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2017
      5. Publication :
        The Journal of Immunology
      6. Products :
      7. Volume :
        N/A
      8. Issue :
        N/A
      9. Page Numbers :
        N/A
      10. Research Area :
        N/A
      11. Keywords :
        IVIS; IVIS BLI in vivo
      12. Abstract :
        Acute graft-versus-host disease (aGVHD) continues to be a frequent and devastating complication of allogeneic hematopoietic stem cell transplantation (HSCT), posing as a significant barrier against the widespread use of HSCTs as a curative modality. Recent studies suggested serum/plasma microRNAs (miRs) may predict aGVHD onset. However, little is known about the functional role of circulating miRs in aGVHD. In this article, we show in two independent cohorts that miR-29a expression is significantly upregulated in the serum of allogeneic HSCT patients at aGVHD onset compared with non-aGVHD patients. Serum miR-29a is also elevated as early as 2 wk before time of diagnosis of aGVHD compared with time-matched control subjects. We demonstrate novel functional significance of serum miR-29a by showing that miR-29a binds and activates dendritic cells via TLR7 and TLR8, resulting in the activation of the NF-κB pathway and secretion of proinflammatory cytokines TNF-α and IL-6. Treatment with locked nucleic acid anti–miR-29a significantly improved survival in a mouse model of aGVHD while retaining graft-versus-leukemia effects, unveiling a novel therapeutic target in aGVHD treatment or prevention.%U http://www.jimmunol.org/content/jimmunol/early/2017/02/02/jimmunol.1601778.full.pdf
      13. URL :
        http://www.jimmunol.org/content/198/6/2500
      14. Call Number :
        PKI @ catherine.lautenschlager @ 13288
      15. Serial :
        13797
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