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      1. Author :
        Kimberly A. Kelly; Nabeel Bardeesy; Rajesh Anbazhagan; Sushma Gurumurthy; Justin Berger; Herlen Alencar; Ronald A. DePinho; Umar Mahmood; Ralph Weissleder
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2008
      5. Publication :
        PLoS Medicine
      6. Products :
      7. Volume :
        15
      8. Issue :
        5
      9. Page Numbers :
        N/A
      10. Research Area :
        Cancer; Biology
      11. Keywords :
        in vivo imaging; cancer
      12. Abstract :
        Background: Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies. The development of molecular markers and imaging probes for incipient PDAC would enable earlier detection and guide the development of interventive therapies. Here we sought to identify novel molecular markers and to test their potential as targeted imaging agents.

        Methods and Findings: Here, a phage display approach was used in a mouse model of PDAC to screen for peptides that specifically bind to cell surface antigens on PDAC cells. These screens yielded a motif that distinguishes PDAC cells from normal pancreatic duct cells in vitro, which, upon proteomics analysis, identified plectin-1 as a novel biomarker of PDAC. To assess their utility for in vivo imaging, the plectin-1 targeted peptides (PTP) were conjugated to magnetofluorescent nanoparticles. In conjunction with intravital confocal microscopy and MRI, these nanoparticles enabled detection of small PDAC and precursor lesions in engineered mouse models.

        Conclusions: Our approach exploited a well-defined model of PDAC, enabling rapid identification and validation of PTP. The developed specific imaging probe, along with the discovery of plectin-1 as a novel biomarker, may have clinical utility in the diagnosis and management of PDAC in humans.
      13. URL :
        http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0050085
      14. Call Number :
        PKI @ sarah.piper @
      15. Serial :
        4478
      1. Author :
        Matthias Nahrendorf; Edmund Keliher; Brett Marinelli; Peter Waterman; Paolo Fumene Feruglio; Lioubov Fexon; Misha Pivovarov; Filip K. Swirski; Mikael J. Pittet; Claudio Vinegoni; Ralph Weissleder
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2010
      5. Publication :
        PNAS
      6. Products :
      7. Volume :
        107
      8. Issue :
        17
      9. Page Numbers :
        N/A
      10. Research Area :
        Cancer
      11. Keywords :
        fluorescence molecular tomography; FMT; Fluorescence Imaging Agents; ProSense; fluorescence-mediated tomography; molecular imaging; multimodal image fusion; computed tomography; cancer
      12. Abstract :
        Fusion imaging of radionuclide-based molecular (PET) and structural data [x-ray computed tomography (CT)] has been firmly established. Here we show that optical measurements [fluorescence-mediated tomography (FMT)] show exquisite congruence to radionuclide measurements and that information can be seamlessly integrated and visualized. Using biocompatible nanoparticles as a generic platform (containing a 18F isotope and a far red fluorochrome), we show good correlations between FMT and PET in probe concentration (r2 > 0.99) and spatial signal distribution (r2 > 0.85). Using a mouse model of cancer and different imaging probes to measure tumoral proteases, macrophage content and integrin expression simultaneously, we demonstrate the distinct tumoral locations of probes in multiple channels in vivo. The findings also suggest that FMT can serve as a surrogate modality for the screening and development of radionuclide-based imaging agents.
      13. URL :
        http://www.pnas.org/content/107/17/7910.abstract?sid=084c1ba8-0b02-4833-acdd-b57bea226faf
      14. Call Number :
        PKI @ sarah.piper @
      15. Serial :
        4468
      1. Author :
        Katharina Jannasch, Jeannine Missbach-Guentner and Frauke Alves
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        N/A
      5. Publication :
        Drug Discovery Today: Disease Models
      6. Products :
      7. Volume :
        6
      8. Issue :
        4
      9. Page Numbers :
        N/A
      10. Research Area :
        Drug Discovery
      11. Keywords :
        FMT; ProSense; in vivo imaging
      12. Abstract :
        The incidence of asthma is increasing throughout the world. Animal models are crucial for understanding the pathophysiology of asthma and for developing new therapies. Novel imaging approaches will be a powerful tool for studying asthma in animal models. This review will give a short overview of different imaging techniques that are currently used and will focus on new developments in visualization of asthma that might be used in animals as well as being translated to humans.
      13. URL :
        http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B75D8-4Y5GVHG-1&_user=10&_coverDate=02%2F28%2F2010&_rdoc=1&_fmt=high&_orig=browse&_origin=browse&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=58c3195065086c72b7aa74f13df11
      14. Call Number :
        PKI @ sarah.piper @
      15. Serial :
        4533
      1. Author :
        Filip K. Swirski, Matthias Nahrendorf, Martin Etzrodt, Moritz Wildgruber, Virna Cortez-Retamozo, Peter Panizzi, Jose-Luiz Figueiredo, Rainer H. Kohler, Aleksey Chudnovskiy, Peter Waterman, Elena Aikawa, Thorsten R. Mempel, Peter Libby, Ralph Weissleder and Mikael J. Pittet
      2. Title :
      3. Type :
        Journal Article
      4. Year :
        2009
      5. Publication :
        Science
      6. Products :
      7. Volume :
        325
      8. Issue :
        5940
      9. Page Numbers :
        N/A
      10. Research Area :
        Cardiovascular Research; Immunology
      11. Keywords :
        splenic monocytes; in vivo imaging; ProSense; FMT; fluorescence molecular tomography
      12. Abstract :
        A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocytes assemble in clusters in the cords of the subcapsular red pulp and are distinct from macrophages and DCs. In response to ischemic myocardial injury, splenic monocytes increase their motility, exit the spleen en masse, accumulate in injured tissue, and participate in wound healing. These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation.
      13. URL :
        http://www.sciencemag.org/content/325/5940/612.abstract
      14. Call Number :
        PKI @ sarah.piper @
      15. Serial :
        4567
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